• • DRAMP ID

  • DRAMP39283

• • Peptide Name

  • PLS-S1

• • Source

  • Phyllomedusa sauvagei (Sauvage's leaf frog)

• • Family

  • Belongs to the frog skin active peptide (FSAP) family. Medusin subfamily.

• • Gene

  • Not found

• • Sequence

  • LLGMIPVAISAISALSKL

• • Sequence Length

  • 18

• • UniProt Entry

• • Protein Existence

  • protein level

• • SMILES

  • Not available

• • Biological Activity

  • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-,Antiprotozoal

• • Target Organism

  • • [Ref.23774944]protozoon: Leishmania amazonensis promastigotes(10% inhibition at 100μM);L. infantum promastigotes(15% inhibition at 100μM);Leishmania amazonensis amastigotes(15% inhibition at 120μM);L. infantum amastigotes(15% inhibition at 120μM)
    • Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus	MIC=5.7μM

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli(MIC=11.5±5.7μM);Xanthomonas axonopodis pv. glycines	MIC=1.42μM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • [Ref.23774944]Will not reduce the macrophages cell viability up to a concentration of approximately 64 µM

• • Binding Target

  • plasma membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Not found

• • Stereochemistry

  • L

• • Structure

• • Structure Description

• • PDB ID

  • Notfound

• Predicted Structure

• There is no predicted structure for DRAMP39283.

DRAMP39283

• ·Literature 1

• • Title

  • The skin secretion of the amphibian Phyllomedusa nordestina: a source of antimicrobial and antiprotozoal peptides.

• • Pubmed ID

  • 23774944

• • Reference

  • Molecules. 2013 Jun 17;18(6):7058-70.

• • Author

  • Brand GD, Santos RC, Arake LM, Silva VG, Veras LM, Costa V, Costa CH, Kuckelhaus SS, Alexandre JG, Feio MJ, Leite JR.