General Information

    • DRAMP ID

    • DRAMP39289

    • Peptide Name

    • MG-H1

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIKKFLHIIWKFIKAFVGEIMNS

    • Sequence Length

    • 23

    • UniProt Entry

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial,Anti-Gram-,Antiprotozoal

    • Target Organism

      • [Ref.15273109]protozoon: L.donovani promastigotes(LD50=2.4µM;LD90=4.3µM)
      • Gram-negative bacteria:
        Target OrganismActivity
        E.coliMIC=16µM

    • Hemolytic Activity

      • [Ref.15273109]ED50=2.9µM

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39289.

Physicochemical Information

    • Formula

    • C133H207N31O28S1

    • Absent Amino Acids

    • Cys,Asp,Pro,Gln,A

    • Common Amino Acids

    • Ala,Glu,P

    • Mass

    • 2720.32

    • PI

    • 10

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.006

    • Aliphatic Index

    • 118.7

    • Half Life

      • Mammalian:30 hours
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 2.02

    • Polar Residues

    • 2

DRAMP39289

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Role of positional hydrophobicity in the leishmanicidal activity of magainin 2.

    • Reference

    • Antimicrob Agents Chemother. 2004 Aug;48(8):2980-6.

    • Author

    • Guerrero E, Saugar JM, Matsuzaki K, Rivas L.