General Information

    • DRAMP ID

    • DRAMP39378

    • Peptide Name

    • Koshidacins B

    • Source

    • Pochonia boninensis FKR-0564

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • XFpX

    • Sequence Length

    • 4

    • UniProt Entry

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antiprotozoal

    • Target Organism

      • [Ref.36282784]protozoon: P. falciparum K1strains(IC50=0.83±0.04µM);P. falciparum FCR3 strains(IC50=0.89 ± 0.04µM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.36282784]CC50=14.7±4.1µM targeting on MRC-5 cells

    • Binding Target

    • histone deacetylase

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Cyclization (N termini to C termini)

    • C-terminal Modification

    • Cyclization (C termini to N termini)

    • Nonterminal Modifications and Unusual Amino Acids

    • X=Aib;X=8-oxo-Ahda

    • Stereochemistry

    • D

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39378.

Physicochemical Information

    • Formula

    • C14H18N2O3

    • Absent Amino Acids

    • Ala,Cys,Asp,Glu,G

    • Common Amino Acids

    • Phe,Pro

    • Mass

    • 262.3

    • PI

    • 5.53

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 1

    • Net Charge

    • 0

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.006

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP39378

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Koshidacins A and B, Antiplasmodial cyclic tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0565.

    • Reference

    • J Nat Prod. 2022 Nov 25;85(11):2641-2649.

    • Author

    • Watanabe Y, Hachiya K, Ikeda A, Nonaka K, Higo M, Muramatsu R, Noguchi C, Honsho M, Asami Y, Inahashi Y, Hirose T, Matsui H, Sunazuka T, Hanaki H, Ishii T, Teruya T, Hokari R, Ishiyama A, Iwatsuki M.