General Information

    • DRAMP ID

    • DRAMP39385

    • Peptide Name

    • Peptide 7

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • QGILR

    • Sequence Length

    • 5

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial,Antiprotozoal

    • Target Organism

      • [Ref.26039561]protozoon: P. falciparum(approx 60% inhibition at 100μM)

    • Hemolytic Activity

      • [Ref.26039561]Non-haemolytic at 10μM concentration

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • palmitoylation

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39385.

Physicochemical Information

    • Formula

    • C100H148N20O34

    • Absent Amino Acids

    • Ala,Cys,Gly,His,L

    • Common Amino Acids

    • Asp,Glu,P

    • Mass

    • 2174.36

    • PI

    • 4.06

    • Basic Residues

    • 2

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -5

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.008

    • Aliphatic Index

    • 85.88

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 0.69

    • Polar Residues

    • 2

DRAMP39385

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion.

    • Reference

    • PLoS One. 2015 Jun 3;10(6):e0127383.

    • Author

    • Bianchin A, Bell A, Chubb AJ, Doolan N, Leneghan D, Stavropoulos I, Shields DC, Mooney C.