General Information

    • DRAMP ID

    • DRAMP39386

    • Peptide Name

    • Peptide 8

    • Source

    • synthetic

    • Family

    • not found

    • Gene

    • not found

    • Sequence

    • AGPAIALVGDAR

    • Sequence Length

    • 12

    • Protein Existence

    • not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(=O)N[C@@H](C)C(=O)O)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial,Antiprotozoal

    • Target Organism

      • [Ref.9799128]protozoon: P. berghei(24±12% inhibition at 100 μM）

    • Hemolytic Activity

      • not found

    • Cytotoxicity

      • not found

    • Binding Target

    • membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39386.

Physicochemical Information

    • Formula

    • C82H143N21O23

    • Absent Amino Acids

    • Ala,Cys,Asp,Phe,G

    • Common Amino Acids

    • Glu,Ile,L

    • Mass

    • 1791.14

    • PI

    • 9.83

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +3

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.006

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 0.83

    • Polar Residues

    • 5

DRAMP39386

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Structural information on a cecropin-like synthetic peptide, Shiva-3 toxic to the sporogonic development of Plasmodium berghei

    • Reference

    • Eur J Biochem. 1998 Oct 1;257(1):263-73

    • Author

    • Boisbouvier J, Prochnicka-Chalufour A, Nieto AR, Torres JA, Nanard N, Rodriguez MH, Possani LD, Delepierre M