General Information

    • DRAMP ID

    • DRAMP39387

    • Peptide Name

    • Peptide 9

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HAVGNDTSNHGVTA

    • Sequence Length

    • 14

    • Protein Existence

    • Not found

    • SMILES

    • CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(N)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C

Activity Information

    • Biological Activity

    • [Ref.36739680]Peptides 9 showed highly significant inhibitions of DENV-4 plaque formation (80.31–83.92%), but lower inhibitions were observed against DENV-1 to 3 (5.34–55.46%); Peptides 9 (200 μM) dem

    • Target Organism

      • [Ref.26039561]protozoon: P. falciparum(approx 35% inhibition at 100μM)

    • Hemolytic Activity

      • [Ref.26039561]Non-haemolytic at 10μM concentration

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • palmitoylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39387.

Physicochemical Information

    • Formula

    • C63H105N19O19

    • Absent Amino Acids

    • Ala,Cys,Phe,Gly,H

    • Common Amino Acids

    • Asp,Glu,L

    • Mass

    • 1432.62

    • PI

    • 8.5

    • Basic Residues

    • 4

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +1

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.02

    • Aliphatic Index

    • 61.82

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 1.04

    • Polar Residues

    • 1

DRAMP39387

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion.

    • Reference

    • PLoS One. 2015 Jun 3;10(6):e0127383.

    • Author

    • Bianchin A, Bell A, Chubb AJ, Doolan N, Leneghan D, Stavropoulos I, Shields DC, Mooney C.