• • DRAMP ID

  • DRAMP39388

• • Peptide Name

  • Peptide 10

• • Source

  • Synthetic

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • SPRTGLDFNEMI

• • Sequence Length

  • 12

• • UniProt Entry

  • Notfound

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(C)=O)[C@@H](C)O)C(N)=O

• • Biological Activity

  • [Ref.36739680]Peptide 10 (200 μM) exhibited inhibitions of all four DENV serotypes, with high inhibitions of DENV-4 at 81.13%, followed by DENV-3 at 60.47% and DENV-1 at 47.01%.

• • Target Organism

  • • [Ref.26039561]protozoon: P. falciparum(approx 38% inhibition at 100μM)

• • Hemolytic Activity

  • • [Ref.26039561]Non-haemolytic at 10μM concentration

• • Cytotoxicity

  • • Not found

• • Binding Target

  • plasma membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • palmitoylation

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Not found

• • Stereochemistry

  • L

• • Structure

• • Structure Description

• • PDB ID

  • Notfound

• Predicted Structure

• There is no predicted structure for DRAMP39388.

DRAMP39388

• ·Literature 1

• • Title

  • Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion.

• • Pubmed ID

  • 26039561

• • Reference

  • PLoS One. 2015 Jun 3;10(6):e0127383.

• • Author

  • Bianchin A, Bell A, Chubb AJ, Doolan N, Leneghan D, Stavropoulos I, Shields DC, Mooney C.