General Information
-
DRAMP ID
- DRAMP39389
-
Peptide Name
- Peptide 11
-
Source
- Synthetic construct
-
Family
- Flaviviridae
-
Gene
- Not found
-
Sequence
- TNTTT
-
Sequence Length
- 5
-
Protein Existence
- Not found
-
SMILES
- CC(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Activity Information
-
Biological Activity
- [Ref.36739680]Peptides 11 at 200 μM exhibited cell protection effects below 50% against all four DENV serotypes(DENV-1, DENV-2, DENV-3, DENV-4); peptides 11 (200 μM) also showed inhibitions of all fou
-
Target Organism
- DENV
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not found
-
Binding Target
- plasma membrane
Structure Information
Physicochemical Information
-
Formula
- C54H95N17O14
Absent Amino Acids
- Cys,Asp,Glu,Phe,G
Common Amino Acids
- Ala,Ile,L
Mass
- 1206.44
PI
- 11
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +2
-
Boman Index
- 0
Hydrophobicity
- -0.001
Aliphatic Index
- 127
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 1.24
Polar Residues
- 3
DRAMP39389
Comments Information
Literature Information
- ·Literature 1
-
Title
- Development of novel antiviral peptides against dengue serotypes 1-4.
-
Pubmed ID
- 36739680
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Reference
- Virology. 2023 Mar;580:10-27.
-
Author
- Lee MF, Anasir MI, Poh CL.
