General Information

    • DRAMP ID

    • DRAMP39390

    • Peptide Name

    • Peptide 12

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DANFV

    • Sequence Length

    • 5

    • Protein Existence

    • Not found

    • SMILES

    • CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(N)=O)C(C)C

Activity Information

    • Biological Activity

    • [Ref.36739680]Peptides 12 at 200 μM exhibited cell protection effects below 50% against all four DENV serotypes(DENV-1, DENV-2, DENV-3, DENV-4); peptide 12 (200 μM) also showed inhibitions of all four

    • Target Organism

      • [Ref.26039561]protozoon: P. falciparum(100% inhibition at 100μM)

    • Hemolytic Activity

      • [Ref.26039561]Non-haemolytic at 10μM concentration

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • palmitoylation

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39390.

Physicochemical Information

    • Formula

    • C55H97N17O14

    • Absent Amino Acids

    • Cys,Asp,Glu,Phe,G

    • Common Amino Acids

    • Ala,Ile,L

    • Mass

    • 1220.46

    • PI

    • 11

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +2

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.001

    • Aliphatic Index

    • 127

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 1.22

    • Polar Residues

    • 3

DRAMP39390

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion.

    • Reference

    • PLoS One. 2015 Jun 3;10(6):e0127383.

    • Author

    • Bianchin A, Bell A, Chubb AJ, Doolan N, Leneghan D, Stavropoulos I, Shields DC, Mooney C.