General Information

    • DRAMP ID

    • DRAMP39393

    • Peptide Name

    • Pemuchiamides B

    • Source

    • Hormoscilla sp.

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • XXVGfPPXlPIfP

    • Sequence Length

    • 13

    • UniProt Entry

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antiprotozoal

    • Target Organism

      • [Ref.39145689]protozoon: T. b. rhodesiense(IC50=5.4±0.1μM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.39145689]IC50=3.9±1.0µM targeting on HeLa cells;IC50=2.1±0.4µM targeting on HL60 cells

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • 3,5,7,9-tetramethylpentadecanoylation

    • C-terminal Modification

    • methylation

    • Nonterminal Modifications and Unusual Amino Acids

    • X1=4-(4-hydroxyphenyl)butanoic acid;X2=3-hydroxy-4-aminobutanoic acid;X3=Tzn;N-methylation at position 5;

    • Stereochemistry

    • D

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39393.

Physicochemical Information

    • Formula

    • C57H82N10O11

    • Absent Amino Acids

    • Ala,Cys,Asp,Glu,H

    • Common Amino Acids

    • Phe,Gly,I

    • Mass

    • 1083.32

    • PI

    • 5.5

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • 0

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.011

    • Aliphatic Index

    • 107

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP39393

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Pemuchiamides A and B, Proline-Rich Linear Lipopeptides, Isolated from a Marine Hormoscilla sp. Cyanobacterium.

    • Reference

    • J Nat Prod. 2024 Sep 27;87(9):2292-2301.

    • Author

    • Irie K, Jeelani G, Nozaki T, Iwasaki A.