General Information

    • DRAMP ID

    • DRAMP39394

    • Peptide Name

    • HRP IIA

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GAHHAADGC

    • Sequence Length

    • 9

    • Protein Existence

    • Not found

    • SMILES

    • C[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N[C@@H](CS)C(=O)O)C(=O)NCC(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial, Antiprotozoal

    • Target Organism

      • [Ref.9497049]protozoon: Plasmodium yoelii nigeriensis(approx 24% inhibition at 100 μM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not found

    • Binding Target

    • Haem

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

Physicochemical Information

    • Formula

    • C32H47N13O12S1

    • Absent Amino Acids

    • Glu,Phe,Ile,Lys,L

    • Common Amino Acids

    • Ala,Cys,A

    • Mass

    • 837.86

    • PI

    • 5.97

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • -1

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.003

    • Aliphatic Index

    • 33.33

    • Half Life

      • Mammalian:30 hours
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP39394

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Synthetic peptides corresponding to a repetitive sequence of malarial histidine rich protein bind haem and inhibit haemozoin formation in vitro.

    • Reference

    • Mol Biochem Parasitol. 1997 Dec 1;90(1):281-7.

    • Author

    • Pandey AV, Joshi R, Tekwani BL, Singh RL, Chauhan VS.