General Information

    • DRAMP ID

    • DRAMP39395

    • Peptide Name

    • HRP IIB

    • Source

    • Synthetic

    • Family

    • not found

    • Gene

    • not found

    • Sequence

    • CGAHHAADAHHAADGC

    • Sequence Length

    • 16

    • Protein Existence

    • not found

    • SMILES

    • C[C@H](NC(=O)CNC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)NCC(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial, Antiprotozoal

    • Target Organism

      • [Ref.9497049]protozoon: Plasmodium yoelii(40-50% inhibition of haem polymerization activity at 100 µM)

    • Hemolytic Activity

      • not found

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39395.

Physicochemical Information

    • Formula

    • C60H86N24O21S2

    • Absent Amino Acids

    • Glu,Phe,Ile,Lys,L

    • Common Amino Acids

    • Ala,Cys,A

    • Mass

    • 1543.6

    • PI

    • 5.98

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -2

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.003

    • Aliphatic Index

    • 37.5

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 0.08

    • Polar Residues

    • 2

DRAMP39395

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Synthetic peptides corresponding to a repetitive sequence of malarial histidine rich protein bind haem and inhibit haemozoin formation in vitro.

    • Reference

    • Mol Biochem Parasitol. 1997 Dec 1;90(1):281-7

    • Author

    • Pandey AV, Joshi R, Tekwani BL, Singh RL, Chauhan VS