General Information

    • DRAMP ID

    • DRAMP39398

    • Peptide Name

    • CA(25-37)M(1-13)

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AVAVVGQATQIAKGIGAVLKVLTTGL

    • Sequence Length

    • 26

    • UniProt Entry

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-

    • Target Organism

      • [Ref.2689223]Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli K12(MIC=200µM);Pseudomonas aeruginosaMIC=300µM
      • Gram-positive bacteria:
        Target OrganismActivity
        Bacillus subtilis(MIC=20µM);Staphylococcus aureus(MIC>300µM);Streptococcus pyogenesMIC=20µM

    • Hemolytic Activity

      • [Ref.2689223]MIC>300µM for sheep red cells

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39398.

Physicochemical Information

    • Formula

    • C112H200N30O32

    • Absent Amino Acids

    • Cys,Asp,Glu,Phe,H

    • Common Amino Acids

    • Ala,Gly,I

    • Mass

    • 2478.97

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +2

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.012

    • Aliphatic Index

    • 150

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP39398

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial and antimalarial properties of peptides that are cecropin-melittin hybrids.

    • Reference

    • FEBS Lett. 1989 Dec 18;259(1):103-6.

    • Author

    • Boman HG, Wade D, Boman IA, Wåhlin B, Merrifield RB.