General Information

    • DRAMP ID

    • DRAMP39400

    • Peptide Name

    • M(16-26)M(1-13)

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LISWIKRKRQQKWKLFKKIEKVGQ

    • Sequence Length

    • 24

    • UniProt Entry

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial,Antibacterial,Anti-Gram+,Anti-Gram-

    • Target Organism

      • [Ref.2689223]Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli K12(MIC=0.7µM);Pseudomonas aeruginosaMIC=8µM
      • Gram-positive bacteria:
        Target OrganismActivity
        Bacillus subtilis(MIC=0.7µM);Staphylococcus aureus(MIC=10µM);Streptococcus pyogenesMIC=1µM

    • Hemolytic Activity

      • [Ref.2689223]MIC>200µM for sheep red cells

    • Cytotoxicity

      • Not found

    • Binding Target

    • plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39400.

Physicochemical Information

    • Formula

    • C145H242N42O31

    • Absent Amino Acids

    • Ala,Cys,Asp,His,M

    • Common Amino Acids

    • Glu,Phe,G

    • Mass

    • 3069.74

    • PI

    • 11.3

    • Basic Residues

    • 9

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +8

    • Boman Index

    • 0

    • Hydrophobicity

    • -0.011

    • Aliphatic Index

    • 93.33

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 3.58

    • Polar Residues

    • 4

DRAMP39400

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial and antimalarial properties of peptides that are cecropin-melittin hybrids.

    • Reference

    • FEBS Lett. 1989 Dec 18;259(1):103-6.

    • Author

    • Boman HG, Wade D, Boman IA, Wåhlin B, Merrifield RB.