General Information

    • DRAMP ID

    • DRAMP39405

    • Peptide Name

    • Cyclo[Val-Lys(Z)]

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VK

    • Sequence Length

    • 2

    • UniProt Entry

    • Protein Existence

    • Not found

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antiprotozoal

    • Target Organism

      • [Ref.23084276]protozoon: P. berghei schizonts(IC50=3.12µM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not found

    • Binding Target

    • binding sites of enzymes and proteins

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Cyclization (N termini to C termini)

    • C-terminal Modification

    • Cyclization (C termini to N termini)

    • Nonterminal Modifications and Unusual Amino Acids

    • Not found

    • Stereochemistry

    • L

    • Structure

    • Structure Description

    • Predicted Structure

    • There is no predicted structure for DRAMP39405.

Physicochemical Information

    • Formula

    • C11H23N3O3

    • Absent Amino Acids

    • Ala,Cys,Asp,Glu,P

    • Common Amino Acids

    • Lys,Val

    • Mass

    • 245.32

    • PI

    • 8.72

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 1

    • Net Charge

    • +1

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.002

    • Aliphatic Index

    • 145

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP39405

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • Linear and cyclic dipeptides with antimalarial activity.

    • Reference

    • Bioorg Med Chem Lett. 2012 Dec 1;22(23):7048-51.

    • Author

    • Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY.