General Information
Activity Information
-
Biological Activity
- Antimicrobial, Antiprotozoal
-
Target Organism
-
- [Ref.23084276]protozoon: P. berghei schizonts(IC50=2.54µM)
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not found
-
Binding Target
- binding sites of enzymes and proteins
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Cyclization (N termini to C termini)
-
C-terminal Modification
- Cyclization (C termini to N termini)
-
Nonterminal Modifications and Unusual Amino Acids
- Not found
-
Stereochemistry
- L
-
Structure
-
Structure Description
-
PDB ID
- Notfound
-
Predicted Structure
- There is no predicted structure for DRAMP39406.
Physicochemical Information
-
Formula
- C18H20N2O3
Absent Amino Acids
- Ala,Cys,Asp,Glu,G
Common Amino Acids
- Phe
Mass
- 312.36
PI
- 5.53
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 2
Net Charge
- 0
-
Boman Index
- 0
Hydrophobicity
- 0.028
Aliphatic Index
- 0
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP39406
Comments Information
Literature Information
- ·Literature 1
-
Title
- Linear and cyclic dipeptides with antimalarial activity.
-
Pubmed ID
- 23084276
-
Reference
- Bioorg Med Chem Lett. 2012 Dec 1;22(23):7048-51.
-
Author
- Pérez-Picaso L, Olivo HF, Argotte-Ramos R, Rodríguez-Gutiérrez M, Rios MY.
