• • DRAMP ID

  • DRAMP39418

• • Peptide Name

  • lachnospirin-1(AMP10.015_742)

• • Source

  • Synthetic construct

• • Family

  • Belongs to the SPHERE-III.008_812 family

• • Gene

  • Not found

• • Sequence

  • LKQLNRFKYKIIKIKRIIKL

• • Sequence Length

  • 20

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • Not available

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.38843834]Gram-positive bacteria:

      Target Organism	Activity
      S. aureus ATCC 12600	MIC>64 μM
      S. aureus ATCC BAA-1556 - MRSA	MIC>64 μM
      E. faecalis ATCC 700802 - VRE	MIC>64 μM
      E. faecium ATCC 700221 - VRE	MIC=1 μM
      C. aerofaciens ATCC 25986	MIC=8 μM
      C. scindens ATCC 35704	MIC=64 μM

    • Gram-negative bacteria:

      Target Organism	Activity
      A. baumannii ATCC 19606	MIC=2 μM
      E. coli ATCC 11775	MIC>64 μM
      E. coli AIC221	MIC>64 μM
      E. coli AIC222 - CRE	MIC>64 μM
      K. pneumoniae ATCC 13883	MIC>64 μM
      P. aeruginosa PAO1	MIC>64 μM
      P. aeruginosa PA14	MIC>64 μM
      A. muciniphila ATCC BAA-835	MIC=64 μM
      B. fragilis ATCC 25285	MIC=64 μM
      B. thetaiotaomicron ATCC 29148	MIC=64 μM
      B. uniformis ATCC 8492	MIC=64 μM
      B. vulgatus ATCC 8482	MIC=64 μM
      P. distasonis ATCC 8503	MIC=64 μM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Alpha helix, turn, random coil in membrane-mimicking; Alpha helix, beta sheet, turn, random coil in water

• • Structure Description

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP39418.

DRAMP39418

• ·Literature 1

• • Title

  • Discovery of antimicrobial peptides in the global microbiome with machine learning

• • Pubmed ID

  • 38843834

• • Reference

  • Cell. 2024 Jul 11;187(14):3761-3778.e49.

• • Author

  • Santos-Júnior CD, Torres MDT, Duan Y, Rodríguez Del Río Á, Schmidt TSB, Chong H, Fullam A, Kuhn M, Zhu C, Houseman A, Somborski J, Vines A, Zhao XM, Bork P, Huerta-Cepas J, de la Fuente-Nunez C, Coelho LP.