General Information

    • DRAMP ID

    • DRAMP39520

    • Peptide Name

    • bsa121

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GWFDVVKHIASAV

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+

    • Target Organism

      • [Ref.40906555]Gram-positive bacteria:
        Target OrganismActivity
        S. aureusMIC=250 μg/mL
      • Gram-negative bacteria:
        Target OrganismActivity
        E. coliMIC=500 μg/mL
        K. pneumoniaeMIC>500 μg/mL
        A. baumanniiMIC=500 μg/mL

    • Hemolytic Activity

      • [Ref.40906555]The hemolysis against sheep blood cells at 100 μg/mL was estimated to be less than 5%.

    • Cytotoxicity

      • [Ref.40906555]The cytotoxicity against human A549 cells at 100 μg/mL (assessed as cell viability) was estimated to be in the range of 90-100%.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP39520.

Physicochemical Information

    • Formula

    • C68H101N17O17

    • Absent Amino Acids

    • Cys,Glu,Leu,Met,A

    • Common Amino Acids

    • Ala,Asp,P

    • Mass

    • 1428.63

    • PI

    • 6.74

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • 0

    • Boman Index

    • 0

    • Hydrophobicity

    • 0.008

    • Aliphatic Index

    • 112.31

    • Half Life

      • Mammalian:30 hours
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 3.85

    • Polar Residues

    • 1

DRAMP39520

Comments Information

Literature Information

  • ·Literature 1

    • Title

    • EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework.

    • Reference

    • Cell Rep. 2025 Sep 23;44(9):116215.

    • Author

    • Zhao Y, Li Q, Sun M, Su Y, Su X, Jiang L, Zhang X, Hu Y, Wang B, Yu H, Zhang Q, Chai Z, Yao D, Ren Y, Huang W, Jin Y, Dou Y, Li D, Huang Z, Liu P, Ren H, Jiang Y.