General Information
-
DRAMP ID
- DRAMP39524
-
Peptide Name
- bsa126
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GLWSKIKEAGKAAFKAAGKAALGAVADAV
-
Sequence Length
- 29
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
-
SMILES
- Not available
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+
-
Target Organism
-
- [Ref.40906555]Gram-positive bacteria:
Target Organism Activity S. aureus MIC=250 μg/mL - Gram-negative bacteria:
Target Organism Activity E. coli MIC=3.91 μg/mL K. pneumoniae MIC=31.25 μg/mL A. baumannii MIC=3.91 μg/mL P. aeruginosa MIC=31.25 μg/mL
- [Ref.40906555]Gram-positive bacteria:
-
Hemolytic Activity
-
- [Ref.40906555]The hemolysis against sheep blood cells at 100 μg/mL was estimated to be less than 5%.
-
Cytotoxicity
-
- [Ref.40906555]The cytotoxicity against human A549 cells at 100 μg/mL (assessed as cell viability) was estimated to be in the range of 90-100%.
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP39524.
Physicochemical Information
-
Formula
- C128H211N35O35
Absent Amino Acids
- Cys,His,Met,Asn,P
Common Amino Acids
- Ala,Asp,G
Mass
- 2800.26
PI
- 9.83
Basic Residues
- 5
Acidic Residues
- 2
Hydrophobic Residues
- 17
Net Charge
- +3
-
Boman Index
- 0
Hydrophobicity
- 0.004
Aliphatic Index
- 94.83
Half Life
-
- Mammalian:30 hours
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 1.96
Polar Residues
- 1
DRAMP39524
Comments Information
Literature Information
- ·Literature 1
-
Title
- EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework.
-
Pubmed ID
- 40906555
-
Reference
- Cell Rep. 2025 Sep 23;44(9):116215.
-
Author
- Zhao Y, Li Q, Sun M, Su Y, Su X, Jiang L, Zhang X, Hu Y, Wang B, Yu H, Zhang Q, Chai Z, Yao D, Ren Y, Huang W, Jin Y, Dou Y, Li D, Huang Z, Liu P, Ren H, Jiang Y.
