• • DRAMP ID

  • DRAMP39528

• • Peptide Name

  • bsa132

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KLAGLAKKLAGLAKKLAGLAK

• • Sequence Length

  • 21

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • Not available

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram-

• • Target Organism

  • • [Ref.40906555]Gram-positive bacteria:

      Target Organism	Activity
      S. aureus	MIC>500 μg/mL

    • Gram-negative bacteria:

      Target Organism	Activity
      E. coli	MIC=3.91 μg/mL
      K. pneumoniae	MIC=125 μg/mL
      A. baumannii	MIC=1.95 μg/mL
      P. aeruginosa	MIC=62.5 μg/mL
      E. coli_1	MIC=15.6 μg/mL
      E. coli_2	MIC=15.6 μg/mL
      E. coli_3	MIC=7.8 μg/mL
      E. coli_4	MIC=15.6 μg/mL
      P. aeruginosa_1	MIC=125.0 μg/mL
      P. aeruginosa_2	MIC=250.0 μg/mL
      P. aeruginosa_3	MIC=62.5 μg/mL
      P. aeruginosa_4	MIC=125.0 μg/mL
      A. baumannii_1	MIC=3.9 μg/mL
      A. baumannii_2	MIC=3.9 μg/mL
      A. baumannii_3	MIC=2.0 μg/mL
      A. baumannii_4	MIC=3.9 μg/mL
      K. pneumoniae_2	MIC=31.3 μg/mL
      K. pneumoniae_3	MIC=250.0 μg/mL
      K. pneumoniae_4 (MIC=62.5 μg/mL):	-

    • Fungi:

      Target Organism	Activity
      C. auris	MIC=125.0 μg/mL
      C. albicans	MIC=2.0 μg/mL

• • Hemolytic Activity

  • • [Ref.40906555]HC50=4552 μg/mL against sheep blood cells; HC50/MIC=2334.36. And the hemolysis against sheep blood cells at 100 μg/mL was estimated to be less than 5%.

• • Cytotoxicity

  • • [Ref.40906555]IC50=658.5 μg/mL against human A549 cells; IC50/MIC=337.69. And the cytotoxicity against human A549 cells at 100 μg/mL (assessed as cell viability) was estimated to be in the range of 90-100%.

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP39528.

DRAMP39528

• ·Literature 1

• • Title

  • EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework.

• • Pubmed ID

  • 40906555

• • Reference

  • Cell Rep. 2025 Sep 23;44(9):116215.

• • Author

  • Zhao Y, Li Q, Sun M, Su Y, Su X, Jiang L, Zhang X, Hu Y, Wang B, Yu H, Zhang Q, Chai Z, Yao D, Ren Y, Huang W, Jin Y, Dou Y, Li D, Huang Z, Liu P, Ren H, Jiang Y.