General Information

    • DRAMP ID

    • DRAMP00068

    • Peptide Name

    • Aureocin A53 (Bacteriocin)

    • Source

    • Staphylococcus aureus A53 (Gram-positive bacteria)

    • Family

    • Belongs to the class II bacteriocin

    • Gene

    • aucA

    • Sequence

    • MSWLNFLKYIAKYGKKAVSAAWKYKGKVLEWLNVGPTLEWVWQKLKKIAGL

    • Sequence Length

    • 51

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](C)CC)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        Listeria monocytogenes-
        Staphylococcus simulansMIC=100 nM
        Staphylococcus aureusMRSA
        Streptococcus agalactiae-
        Micrococcus luteusMIC=0.15 nM

    • Hemolytic Activity

      • [Ref.12054867] No hemolytic activity was detected when purified aureocin A53 was spotted on sheep blood agar plates (data not shown in the reference).

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Formylation

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Predicted Structure

    • There is no predicted structure for DRAMP00068.

Physicochemical Information

    • Formula

    • C291H447N69O65S

    • Absent Amino Acids

    • CDHR

    • Common Amino Acids

    • K

    • Mass

    • 5984.23

    • PI

    • 10.07

    • Basic Residues

    • 10

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 24

    • Net Charge

    • +8

    • Boman Index

    • -7.5

    • Hydrophobicity

    • -0.084

    • Aliphatic Index

    • 101.37

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 31970

    • Absorbance 280nm

    • 639.4

    • Polar Residues

    • 12

DRAMP00068

Comments Information

    • Function

    • Antibacterial peptide. It causes membrane permeation.

Literature Information

  • ·Literature 1

    • Title

    • Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus.

    • Reference

    • J Mol Biol. 2002 Jun 7;319(3):745-756.

    • Author

    • Netz DJ, Pohl R, Beck-Sickinger AG, Selmer T, Pierik AJ, Bastos Mdo C, Sahl HG.