• • DRAMP ID

  • DRAMP01004

• • Peptide Name

  • Cucurmoschin (Plants)

• • Source

  • Cucurbita maxima (winter squash)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • PQRGEGGRAGNLLREEQEI

• • Sequence Length

  • 19

• • UniProt Entry

  • P84158

• • Protein Existence

  • Protein level

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CC[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O

• • Biological Activity

  • Antimicrobial, Antifungal

• • Target Organism

  • • Fungi:

      Target Organism	Activity
      Botrytis cinerea	MIC=375 µM
      Fusarium oxysporum	MIC=375 µM
      Mycosphaerella arachidicola	MIC=375 µM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01004.

DRAMP01004

• • Function

  • Has antifungal activity. Inhibits cell-free translation in rabbit reticulocyte lysate system.

• ·Literature 1

• • Title

  • Isolation of cucurmoschin, a novel antifungal peptide abundant in arginine, glutamate and glycine residues from black pumpkin seeds.

• • Pubmed ID

  • 14499274

• • Reference

  • Peptides. 2003 Jul;24(7):969-972.

• • Author

  • Wang HX, Ng TB.