General Information

    • DRAMP ID

    • DRAMP01012

    • Peptide Name

    • Pg-AMP (Gly-rich; Plants)

    • Source

    • Psidium guajava (Guava)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RESPSSRMECYEQAERYGYGGYGGGRYGGGYGSGRGQPVGQGVERSHDDNRNQPR

    • Sequence Length

    • 55

    • Protein Existence

    • Protein level

    • SMILES

    • CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Klebsiella sp.-
        Proteus sp.-
        Escherichia coli ATCC 8739MIC=72 mg/ml
        Klebsiella pneumoniaeMIC=32 mg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01012.

Physicochemical Information

    • Formula

    • C248H373N87O87S2

    • Absent Amino Acids

    • FIKLTW

    • Common Amino Acids

    • G

    • Mass

    • 6029.34

    • PI

    • 8.13

    • Basic Residues

    • 9

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -202.11

    • Hydrophobicity

    • -1.678

    • Aliphatic Index

    • 12.36

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8940

    • Absorbance 280nm

    • 165.56

    • Polar Residues

    • 28

DRAMP01012

Comments Information

    • Function

    • Has antibacterial activity against the Gram-negative bacteria. Does not have antifungal activity against the human and plant pathogenic fungi F. oxysporum, A. fumigatus and R. solani.

    • Subunit structure

    • Monomer and homodimer. Might act by homodimer formation.

Literature Information

  • ·Literature 1

    • Title

    • Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria.

    • Reference

    • Peptides. 2008 Aug;29(8):1271-1279.

    • Author

    • Pelegrini PB, Murad AM, Silva LP, Dos Santos RC, Costa FT, Tagliari PD, Bloch C Jr, Noronha EF, Miller RN, Franco OL.