• • DRAMP ID

  • DRAMP01096

• • Peptide Name

  • Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)

• • Source

  • Bombina orientalis (Oriental fire-bellied toad)

• • Family

  • Belongs to the bombinin family

• • Gene

  • Not found

• • Sequence

  • GIGSAILSAGKSALKGLAKGLAEHFAN

• • Sequence Length

  • 27

• • UniProt Entry

  • P29003

• • Protein Existence

  • Protein level

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O)[C@H](C)CC

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.1744108]Gram-negative bacterium:

      Target Organism	Activity
      58% inhibition Neisseria meningitidis 118V C	MIC=20 µg/ml
      98% inhibition Neisseria meningitidis 15240 IAI	MIC=20 µg/ml
      98% inhibition Neisseria meningitidis 126E IC1	MIC=20 µg/ml
      97% inhibition Neisseria gonorrhoeoe F62	MIC=20 µg/ml
      99% inhibition Neisseria Iactamica 15323	MIC=20 µg/ml
      100% inhibition Neisseria Iactamica 15215A	MIC=20 µg/ml
      95% inhibition Neisseria cinerea 15461	MIC=20 µg/ml

• • Hemolytic Activity

  • • [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01096.

DRAMP01096

• • Function

  • Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.

• • Pubmed ID

  • 1744108

• • Reference

  • J. Biol. Chem. 1991; 266: 23103-23111.

• • Author

  • Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER.