• • DRAMP ID

  • DRAMP03688

• • Peptide Name

  • TsAP-2 (T. serrulatus antimicrobial peptide 2; scorpions, arachnids, invertebrates, animals)

• • Source

  • Tityus serrulatus (Brazilian yellow scorpion)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • FLGMIPGLIGGLISAFK

• • Sequence Length

  • 17

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O)[C@H](C)CC

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Anti-cancer

• • Target Organism

  • • Gram-positive bacterium:

      Target Organism	Activity
      Staphylococcus aureus	MIC=5 µM

    • Yeast:

      Target Organism	Activity
      Candida albicans	MIC=10 µM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP03688.

DRAMP03688

• • Function

  • TsAP-2 was of high potency against the Gram-positive bacterium, Staphylococcus aureus and the yeast Candida albicans.

• ·Literature 1

• • Title

  • Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.

• • Pubmed ID

  • 23770440

• • Reference

  • Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8.

• • Author

  • Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C.