General Information

    • DRAMP ID

    • DRAMP38126

    • Peptide Name

    • SAH-HR2-D-PEG20-TC

    • Sequence

    • DISGINASVVNI8KEIDRLXEVAKNLNESLIDLQELG(K*)

    • Sequence Length

    • 38

    • Original Sequence

    • DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG

    • Source

    • Synthetic Construct

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Comments

    • Not Available

    • Target Organism

      • [Ref:38177138]PV:IC50=4.3 × 10⁻⁹ in B.1.1.529.1 strain, SARS-CoV:IC50=2.3 × 10⁻⁸, LV:IC50=7.2 × 10⁻⁸ against Beta strain (B.1.351)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

Structure Information

    • Linear/Cyclic

    • Cyclic (Stapled)

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Free

    • Special Amino Acid and Stapling Position

    • Staple location is D and it is tricholeaterol with peg length is 20

    • Stereochemistry

    • L

    • Secondary Structure

    • Not Available

    • Structure Description

    • Not Available
  • There is no predicted structure for DRAMP38126.

Literature Information

  • Literature 1

    • Title

    • A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

    • Reference

    • Nat Commun. 2024 Jan 4;15(1):274.

    • Author

    • Bird GH, Patten JJ, Zavadoski W, Barucci N, Godes M, Moyer BM, Owen CD, DaSilva-Jardine P, Neuberg DS, Bowen RA, Davey RA, Walensky LD.