General Information

    • DRAMP ID

    • DRAMP29861

    • Peptide Name

    • Sub3-D

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • aRRWRIVVIRVRRh

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]cn1)C(N)=O)C(C)C)[C@H](C)CC)C(C)C)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Pseudomonas aeruginosa(MIC=2 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus(MIC=1 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Mouse serum

    • Stability Data

    • With a half-life of approximately 1 h

    • Assay

    • RP-HPLC

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • D-Ala at 1st position, D-His at 14th position

    • Stereochemistry

    • Mixed

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP29861.

Literature Information

  • ·Literature 1

    • Title

    • Easy strategy to protect antimicrobial peptides from fast degradation in serum.

    • Reference

    • Antimicrob Agents Chemother. 2010 Sep;54(9):4003-5.

    • Author

    • Knappe D, Henklein P, Hoffmann R, Hilpert K.