General Information

    • DRAMP ID

    • DRAMP29917

    • Peptide Name

    • All-D-CATH-2(C1-15)(F2,5,12 W）

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • rwgrwlrkirrwrpk

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@H](C)[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCCN)C(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Human serum

    • Stability Data

    • Cyclization of F2,5,12W fur-ther improved the stability in serum; in the presence of serumthe peptide maintained its antibacterial activity up to 6h

    • Assay

    • Radial diffusion assays

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • D-Arg at D-Ala at 1st position, D-His at 9th position, D-Trp at D-Ala at 1st position, D-His at 9th position, D-Gly at 3rd position, D-Leu at 6th position, D-Ala at 1st position, D-His at 9th position

    • Stereochemistry

    • D

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP29917.

Literature Information

  • ·Literature 1

    • Title

    • Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization.

    • Reference

    • Peptides. 2011 May;32(5):875-80

    • Author

    • Molhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ.