General Information

    • DRAMP ID

    • DRAMP37308

    • Peptide Name

    • Magainin-Thanatin (MT)

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIGKFLHSAKKFPVPIIYCNRRTGKCQRM

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus(MIC=16.5μM), Bacillus subtilis (MIC=9μM)
      • Gram-negative bacteria: Escherichia coli DH5α(MIC=20μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • The secondary structure mainly contains α-helices (h), accounting for 20.69%; extended chains (e), accounting for 24.14%; β-sheets (t), accounting for 10.34%; and random coils (c), accounting for 44.83%.

    • Predicted Structure

    • There is no predicted structure for DRAMP37308.

Literature Information

  • ·Literature 1

    • Title

    • 杂合抗菌肽MT在大肠杆菌中的融合表达；Fusion expressing of magainin and thanatin hybrid antibacterial peptide in Escherichia coli

    • doi

    • 10.19481/j.cnki.issn2096-398x.2018.03.013.

    • Reference

    • [J].陕西科技大学学报,2018,36(03):68-77.DOI:10.19481/j.cnki.issn2096-398x.2018.03.013.

    • Author

    • 龚国利,张帝,苏鹏：GONG Guo-li ZHANG Di SU Peng WEI Yuan