General Information

    • DRAMP ID

    • DRAMP37325

    • Peptide Name

    • [G4、T5、N8K]Temporin-1Dra

    • Source

    • Sythetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HFLKKLVKLAKKIL

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • Fungus: Canidia albicans ATCC 98001(MIC=64μg/mL), Canidia albicans resistant 1、2、4、8(MIC=128μg/mL)， Canidia albicans 3、5、6、7、9、10(MIC=64μg/mL)，FLC-resistant Canidia albicans(MIC=128μg/mL).

    • Hemolytic Activity

      • The hemolysis rate was less than 5% in the range of 128μg·mL-1(MIC). 1% Triton X-100 were used as the positive control.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix( 6 residues)

    • Structure Description

    • The secondary structure consisted of α-helix (6 amino acid residues), accounting for 42.86%; Extended chain (2 amino acid residues involved), accounting for 14.29%; Random curling (6 amino acid residues involved) accounted for 42.86%.

    • Predicted Structure

    • There is no predicted structure for DRAMP37325.

Literature Information

  • ·Literature 1

    • Title

    • 人工合成抗菌肽生物信息学分析及其抑菌活性研究：Bioinformatics and Antimicrobial Activity of a Remoulded Antimicrobial Peptide

    • doi

    • 10.13664/j.cnki.pcr.2020.04.003.

    • Reference

    • [J].药学与临床研究,2020,28(04):251-254.DOI:10.13664/j.cnki.pcr.2020.04.003.

    • Author

    • 练家惠,陈向东,汪辉： LIAN Jiahui CHEN Xiangdong WANG Hui CHEN Quanshun