Patent Information

    • DRAMP ID

    • DRAMP36093

    • Sequence

    • KITRCPMIPCYISSPDE

    • Sequence Length

    • 17

    • Sequence Name

    • aa 129-145; partial loop-4+loop-5

    • Source

    • Synthetic

    • SMILES

    • CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O

    • Activity

    • Antimicrobial, Anticancer

    • Patent Type

    • Granted Patent

    • Publication Date

    • 2002-7-4

    • Patent Title

    • Novel antiangiogenic peptides

    • Abstract

    • The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1 or a portion thereof which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the portion has at least 50% inhibition of bFGF-stimulated EC proliferation at 5 Tg/ml, more preferably 75% inhibition, most preferably 95% inhibition.