General Information

    • DRAMP ID

    • DRAMP00208

    • Peptide Name

    • Acidocin 8912 (Bacteriocin)

    • Source

    • Lactobacillus acidophilus TK8912 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • acdT

    • Sequence

    • KTHYPTNAWKSLWKGFWESLRYTDGF

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00208 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00208.

Physicochemical Information

    • Formula

    • C154H212N38O39

    • Absent Amino Acids

    • CIMQV

    • Common Amino Acids

    • KTW

    • Mass

    • 3219.61

    • PI

    • 9.4

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +3

    • Boman Index

    • -46.71

    • Hydrophobicity

    • -1.012

    • Aliphatic Index

    • 33.85

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 19480

    • Absorbance 280nm

    • 779.2

    • Polar Residues

    • 10

DRAMP00208

DRAMP00208 chydropathy plot

Comments Information

    • Function

    • Has a bactericidal effect on sensitive cells but not a bacteriolytic effect.

Literature Information

  • ·Literature 1

    • Title

    • Cloning and nucleotide sequence of the gene for acidocin 8912, a bacteriocin from Lactobacillus acidophilus TK8912.

    • Reference

    • Lett Appl Microbiol. 1995 Dec;21(6):384-386.

    • Author

    • Kanatani K, Tahara T, Oshimura M, Sano K, Umezawa C.
  • ·Literature 2

    • Title

    • Purification and some properties of acidocin 8912, a novel bacteriocin produced by Lactobacillus acidophilus TK8912.

    • Reference

    • Biosci Biotechnol Biochem. 1992 Aug;56(8):1212-1215.

    • Author

    • Tahara T, Kanatani K, Yoshida K, Miura H, Sakamoto M, Oshimura M.