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DRAMP ID	NAME	Description	Medical_use	Stage of development	Company
DRAMP18057	MSI-78(Pexiganan, Locilex)	Pexiganan is a broad-spectrum synthetic analogue of the African frog peptide magainin.	Infected diabetic foot ulcers	Phase III(Failure)	Genaera (Plymouth, PA)
DRAMP18058	Daptomycin(Cubicin, LY-164032)	Daptomycin is a cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus.	Treatment of complicated skin and skin structure infections (cSSSI), Staphylococcus aureus bloodstream infections (bacteremia)	In market	Cubist Pharmaceuticals LLC (Merck & Co.)
DRAMP18059	Iseganan(IB-367)	Iseganan is a synthetic analogue of Protegrin I (IBL-367, the pig protegrin derivative), extracted from porcine leukocytes.	①Prevention of Ventilator-Associated Pneumonia; ②Prevention of oral complications caused by radiation therapy for head and neck cancer.	Phase III(Failure)	Intrabiotics Pharmaceuticals Inc.(Mountain View, CA)
DRAMP18060	p2TA(AB103, Reltecimod)	Reltecimod is under investigation in clinical trial NCT02469857 (Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections).	Necrotizing soft tissue infections	Phase III	Atox Bio Ltd.
DRAMP18061	Histatin	using a variant of histatins, which are naturally occurring cationic peptides in saliva	antimicrobial-peptide-containing mouth wash for the treatment of oral candidiasis (gingivitis and periodontal diseases)	Phase II-III	Demgen and Dow Pharmaceutical Sciences;licensed to the Vancouver, Canada, company Pacgen
DRAMP18062	Ramoplanin(NTI-851)	Ramoplanin(NTI-851) is a macrocyclic glycolipodepsipeptideproduced by Actinoplanesspp. being developed by Nano-therapeutics.It exhibits bactericidal activity by blocking the cell wall peptidoglycansynthesis of gram-positive bacteria. Recently, the phase III clinicalstudy of the peptide was initiated for the oral treatment ofvancomycin-resistantenterococcus(VRE) colonization, as well as the phase II trial against Clostridium difficile.	Treatment of bacterial infections.	Phase III	Nano-therapeutics
DRAMP18063	P113	a 12 amino acid fragment of histatin 5	Reduce gum bleeding, gingivitis and plaque	Phase II	Demgen
DRAMP18064	P113D	a 12 amino acid fragment of histatin 5	an inhalation treatment for Pseudomonas aeruginosainfections in cystic fibrosis patients	Unknown	Demgen
DRAMP18067	Dalbavancin (BI397, Dalvance, Xydalba)	Dalbavancin is a semisynthetic lipoglycopeptide and derivate of teicoplanin. It is an antibacterial used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible strains of Gram-positive bacteria.	Acute bacterial skin infections, Osteomyelitis and septic arthritis(Phase IV)	In market	Allergan (formerly Actavis and Durata Therapeutics)
DRAMP18068	hLF1-11(Human lactoferrin 1-11)	hLF1-11 was significantly more effective than the full length protein or the peptide representing the second cationic domain. As with other antimicrobial peptides, hLF1-11 shows poor antimicrobial activity under physiological conditions in vitro, but it is highly effective in vivo against infections due to a variety of microorganisms, including Gram negative and Gram positive bacteria and fungi. The objective is to develop hLF1-11 for the treatment of fungal and bacterial infections that develop during neutropenia that results from myeloablative therapy to prepare for a haematopoietic stem cell transplant(HSCT) formerly referred to as bone marrow transplant.	Bacteraemia and fungal infections in immunocompromized haematopoetic stem cell transplant recipients	Phase I-II	AM-Pharma Holding BV
DRAMP18069	rBPI21(Neuprex)	a human bactericidal permeability protein derivative	meningococcaemia;prophylactic treatment of infectious complications from post-traumatic bleeding (in 842 patients)	Phase III(Failure)	Xoma Ltd(Berkeley, CA, USA)
DRAMP18070	XMP 629(HY-P2170; CS-0109623)	extracted from human	Impetigo and acne rosacea	Phase III	Xoma Ltd(Berkeley, CA, USA)
DRAMP18071	Mycoprex	extracted from insects	Fungal infections	Phase III	Xoma Ltd.
DRAMP18072	Heliomocin variants(ETD151)	an antifungal 44 amino acid peptide, variant of a natural peptide from lepidopteran Heliothis virescens	Systemic fungal infections in immunocompromised patients and multi-resistant bacterial infections	Preclinical	EntoMed SA
DRAMP18073	PG-1	Protegrin Class	Treatment of peritoneal infections caused by P. aeruginosa and S. aureus.Treatment of pneumonia	Unknown	Intrabiotics
DRAMP18074	CSA-13	cationic steroid (ceragenin) that mimics host-defense peptides	Anti-infective	Preclinical	Ceragenix(Denver)
DRAMP18075	HB-50	synthetic natural peptide mimetic of cecropin	Anti-infective	Preclinical	Helix Biomedix(Bothell, Washington, USA)
DRAMP18076	HB-107	19-amino-acid fragment of cecropin B	Wound healing	Preclinical	Helix Biomedix(Bothell, Washington, USA)
DRAMP18077	HB-1345	Synthetic Lipohexapeptide	acne,broad-spectrum antibiotic	Pre-Phase I	Helix Biomedix (Bothell, Washington, USA).
DRAMP18078	HB1275	A lipohexapeptide with potent antifungal activity against yeast and filamentous fungi	Trichophyton infections	Preclinical	Helix Biomedix (Bothell, Washington, USA).