Sequence Information

    • DRAMP ID

    • DRAMP18064

    • Name

    • P113D

    • Sequence

    • akrhhgykrkfh

    • Description

    • a 12 amino acid fragment of histatin 5

    • Activity

    • Antifungal

    • Target Organism

      • nonmucoid P. aeruginosa strain ATCC 27853(LD90=1.25 μg/ml ).P-113D was also as active as P-113 against the battery ofP. aeruginosa clinical isolates.

    • Reference

      • Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)
      • P-113D, an Antimicrobial Peptide Active againstPseudomonas aeruginosa, Retains Activity in the Presence of Sputum from Cystic Fibrosis Patients.Antimicrob. Agents Chemother.(2001)(PMID: 11709321)

Clinical Information

    • Medical use

    • an inhalation treatment for Pseudomonas aeruginosainfections in cystic fibrosis patients

    • Company

    • Demgen

    • Stage of Development

    • Unknown

    • Comments

    • No more comments

    • Clinical Trials