General Information

    • DRAMP ID

    • DRAMP00219

    • Peptide Name

    • PlnA-22 (Bacteriocin)

    • Source

    • Lactobacillus plantarum (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • YSLQMGATAIKQVKKLFKKWGW

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Lactobacillus sake NCDO 2714 (IC50=40 nM), Lactobacillus plantarum 965 (IC50=300 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00219 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00219.

Physicochemical Information

    • Formula

    • C125H195N31O28S

    • Absent Amino Acids

    • CDEHNPR

    • Common Amino Acids

    • K

    • Mass

    • 2612.17

    • PI

    • 10.3

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +5

    • Boman Index

    • -10.65

    • Hydrophobicity

    • -0.332

    • Aliphatic Index

    • 75.45

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 12490

    • Absorbance 280nm

    • 594.76

    • Polar Residues

    • 5

DRAMP00219

DRAMP00219 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structure and mode of action of the membrane-permeabilizing antimicrobial peptide pheromone plantaricin A.

    • Reference

    • J Biol Chem. 2005 Jun 17;280(24):22945-22950.

    • Author

    • Kristiansen PE, Fimland G, Mantzilas D, Nissen-Meyer J.