General Information

    • DRAMP ID

    • DRAMP03567

    • Peptide Name

    • KR-20 (Derived from LL-37)

    • Source

    • Homo sapiens (Human sweat)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KRIVQRIKDFLRNLVPRTES

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus mprF (MIC=16 µM), Staphylococcus aureus ATCC 25923 (MIC>64 µM), Staphylococcus aureus (GAS) (MIC=4 µM);
      • Gram-negative bacterium: Escherichia coli O29 (MIC>64 µM).
      • Yeast: Candida albicans ATCC 14053 (MIC=10 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03567 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03567.

Physicochemical Information

    • Formula

    • C109H190N36O29

    • Absent Amino Acids

    • ACGHMWY

    • Common Amino Acids

    • R

    • Mass

    • 2468.93

    • PI

    • 11.55

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -73.72

    • Hydrophobicity

    • -0.755

    • Aliphatic Index

    • 107

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP03567

DRAMP03567 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.

    • Reference

    • J Immunol 2004; 172: 3070-3077.

    • Author

    • Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL.