General Information

    • DRAMP ID

    • DRAMP03568

    • Peptide Name

    • RK-31 (Derived from LL-37)

    • Source

    • Homo sapiens (Human sweat)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

    • Sequence Length

    • 31

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 µM), Staphylococcus aureus ATCC 25923 (MIC=16 µM), Group A Staphylococcus aureus (GAS) (MIC=8 µM);
      • Gram-negative bacterium: Escherichia coli O29 (MIC=8 µM);
      • Yeast: Candida albicans ATCC 14053 (MIC=4 µM).

    • Hemolytic Activity

      • [Ref.14978112]6% hemolytic activity at 44 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03568 helical wheel diagram
  • 2K6O-> 

    • Predicted Structure

Physicochemical Information

    • Formula

    • C169H292N54O45

    • Absent Amino Acids

    • ACHMWY

    • Common Amino Acids

    • K

    • Mass

    • 3800.51

    • PI

    • 11.04

    • Basic Residues

    • 11

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +7

    • Boman Index

    • -119.02

    • Hydrophobicity

    • -1.165

    • Aliphatic Index

    • 81.61

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03568

DRAMP03568 chydropathy plot

Comments Information

    • Function

    • Has hemolytic activity against human erythrocytes .

Literature Information

  • ·Literature 1

    • Title

    • Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.

    • Reference

    • J Immunol 2004; 172: 3070-3077.

    • Author

    • Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL.