General Information

    • DRAMP ID

    • DRAMP18374

    • Peptide Name

    • hBD-6 (human beta-defensin 6)

    • Source

    • Homo sapiens

    • Family

    • Belongs to the beta-defensin family.

    • Gene

    • Not found

    • Sequence

    • FFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPSGSIID

    • Sequence Length

    • 45

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Chemotactic

    • Target Organism

      • Gram-negative bacteria: E. coli K12.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • beta

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18374 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP18374.

Physicochemical Information

    • Formula

    • C212H355N61O67S6

    • Absent Amino Acids

    • HMVWY

    • Common Amino Acids

    • K

    • Mass

    • 5022.88

    • PI

    • 8.63

    • Basic Residues

    • 8

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -8699

    • Hydrophobicity

    • -0.473

    • Aliphatic Index

    • 71.56

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 8.52

    • Polar Residues

    • 18

DRAMP18374

DRAMP18374 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

    • Reference

    • J Immunol. 2002 Sep 1;169(5):2516-23

    • Author

    • Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y.