Sequence Information

    • DRAMP ID

    • DRAMP29324

    • Name

    • Friulimicin B

    • Sequence

    • Not available

    • Description

    • Friulimicin B is a naturally occurring antibiotic produced by a micro-organism, *Actinoplanes friuliensis*. It shows strong cidal activity against a number of Gram-positive pathogens which commonly cause serious infections in hospital patients and which are becoming more routinely acquired in the community.

    • Activity

    • Antibacterial

    • Target Organism

    • Reference

      • Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles.(PMID: 26041368)

Clinical Information

    • Medical use

    • Pneumonia, staphylococcal skin infections

    • Company

    • MerLion/Pharmaceuticals

    • Stage of Development

    • Phase I

    • Comments

    • Friulimicin B, in the presence of calcium, forms a complex with a lipid carrier that acts in cell wall biosynthesis and which is not targeted by other antibiotics currently in use. Friulimicin B appears to block two essential pathways in the cell envelope and the complexes formed prevent the formation of a functional cell wall.

    • Clinical Trials

    • NCT00492271