Browse Create and Mine Antimicrobial Peptides

NEWS:

DRAMP newly added peptides with reported activities against: SARS-CoV-2.

Commitment:

We are responsible for maintaining the website daily and updating the database regularly. The updated information will be written in the Update page. Last updated on 2024-5-22.

260903 opens since May 20 2013.

External Links

  •         

  •         

  •         

  •         

  •         

  •         
Contact: Zheng Heng, Ph.D.
zhengh18@hotmail.com

Institute of Medical and Pharmaceutical Biotechnology, Jiangsu Industrial Technology Research Institute.

Hanmei Xu: Director of Jiangsu Province Synthetic Peptide Drug Discovery and Evaluation Engineering Research Center.

Welcome to DRAMP Database

DRAMP(Data repository of antimicrobial peptides) is an open-access and manually curated database harboring diverse annotations of AMPs including sequences, structures, activities, physicochemical, patent, clinical and reference information. The clinical dataset also includes information on the clinical trial phase, therapeutic applications, company and preclinical or clinical AMP literature sources.

DRAMP currently contains 29838 entries. DRAMP V4.0 has released. The new version particularly focuses on the clinical translation of antimicrobial peptides. To this end, we added new annotations on the serum stability and protease stability of antimicrobial peptides, which are not be included in current antimicrobial peptide databases. At the same time, the new version of the database has also undergone comprehensive updates in terms of hemolysis and cytotoxicity, adding new AMPs in clinical research and newly reported AMPs.

Data in the DRAMP is made available under an CCBY 4.0 License. You are entitled to access and use the services and download or extract data. The free services are offered for the purpose of providing access to summarized data, analytics, metadata, and bulk downloads. If you need the data from the DRAMP for research, please cite the article of original author for general and clinical AMPs, or obtain the authorization for patent AMPs.

We will conduct data mining and design work based on data collected of DRAMP, as those data are valuable for guiding develment and optimization of AMP-drugs. Prediction function based on computational strategies is also expected in our database. We will set out to establish Some high-efficient classifiers.

To all regular downloads, please cite our publications. If you find some errors in the website, please send an email to 970254590@qq.com.

Read more

*Citation*:

  • Shi G, Kang X, Dong F, Liu Y, Zhu N, Hu Y, Xu H, Lao X, Zheng H. DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides. Nucleic Acids Res. 2022 Jan 7;50(D1):D488-D496. PMID: 34390348
  • New Released Structures

    NEWS & EVENTS

    • May 22,2024 172 patent peptides have been updated in DRAMP.
    • Apr 11,2024 DRAMP V4.0 has released.
    • March 23,2024 Database maintenance have been performed to ensure optimal performance and data integrity.
    • Feb 28,2024 185 patent peptides have been updated in DRAMP.
    • Jan 16,2024 119 patent peptides have been updated in DRAMP.
    • Nov 4,2023 29 stapled peptides have been updated in DRAMP.
    • Aug 16,2023 Stability information has been added to DRAMP.
    • July 4,2023 PDB ID of 95 entries with reported structure in PDB database have been updated.
    • May 17,2023 We have updated information of clinical entries. Besides, 25 new clinical entries are added to DRAMP and some duplicate entries have been deleted.
    • Feb 11,2023 250 predicted structures are added to DRAMP.
    • Dec 1,2022 We have updated information of 200 AMPs existed in DRAMP, especially about N-terminal modification, C-terminal modification, other modifications, Stereochemistry and Cytotoxicity.
    • MORE...

    About Us

    The database is developed by Dr.Zheng's team. This is the home page of the database, please use the navigation bar in the top of page to browse the database. If you encounter any problems in using this database, you can consult the FAQs/help pages for help or feedback to us, we will help you solve as soon as possible.

    Close
    Sign in     login

    Forgot your password?