• • DRAMP ID

  • DRAMP00171

• • Peptide Name

  • Lactocyclicin Q (Bacteriocin)

• • Source

  • Lactococcus sp. strain QU 12 (Gram-positive bacteria)

• • Family

  • Belongs to the class IIc bacteriocin

• • Gene

  • lycQ

• • Sequence

  • LIDHLGAPRWAVDTILGAIAVGNLASWVLALVPGPGWAVKAGLATAAAIVKHQGKAAAAAW

• • Sequence Length

  • 61

• • UniProt Entry

  • B9ZZY0

• • Protein Existence

  • Predicted

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacteria: Lactococcus sp.strain QU 12 (MIC=34.3 µM), Lactococcus lactis subsp.lactis JCM 7638 (MIC=0.141 µM), L. lactis subsp.lactis ATCC 19435 (MIC=0.141 µM), L. lactis subsp.lactis IL1403 (MIC=0.141 µM), L. lactis QU 1 (MIC=0.141 µM), L. lactis subsp.cremoris ATCC 19275 (MIC=0.283 µM), Lactococcus raffinolactis JCM 5706 (MIC=0.71 µM), Lactobacillus sakei subsp.sakei JCM 1157 (MIC=0.015 µM), Lactobacillus casei subsp.casei JCM 1134 (MIC=2.27 µM), Leuconostoc brevis JCM 1059 (MIC=1.14 µM), L. acidophilus JCM 1132 (MIC=2.86 µM), L. coryniformis subsp.coryniformis JCM 1164 (MIC=2.86 µM), L. kimchii JCM 10707 (MIC=0.71 µM), L. mesenteroides subsp.mesenteroides JCM 6124 (MIC=1.03 µM), Weissella cibaria JCM 12495 (MIC=0.71 µM), Pediococcus pentosaceus JCM 5885 (MIC=0.55 µM), P. pentosaceus JCM 5890 (MIC=2.86 µM), P. acidilactici JCM 8797 (MIC=2.86 µM), P. dextrinicus JCM 5887 (MIC=0.141 µM), Enterococcus faecium JCM5804 (MIC=0.71 µM), E. hirae ATCC 10541 (MIC=0.71 µM), E. durans NBRC 100479 (MIC=0.71 µM), E. faecalis JCM 5803 (MIC=0.26 µM), Streptococcus salivarius JCM 5707 (MIC=22.9 µM), S. bovis JCM 5802 (MIC=22.9 µM), Bacillus coagulans JCM 2257 (MIC=0.015 µM), B. circulans JCM 2504 (MIC=0.031 µM), B. subtilis JCM 1465 (MIC=0.064 µM), B. cereus JCM 2152 (MIC=11.4 µM), Micrococcus luteus IFO 12708 (MIC=5.7 µM), Listeria innocua ATCC 33090 (MIC=1.03 µM), L. monocytogenes ATCC BAA-679 (MIC=1.03 µM), Staphylococcus aureus subsp.aureus ATCC 12600 (MIC=91.6 µM); Gram-negative bacteria: Escherichia coli JM109 (MIC=34.3 µM), E. coli NBRC 3301 (MIC=17.3 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Cyclization (N termini to C termini)

• • C-terminal Modification

  • Cyclization (C termini to N termini)

• • Nonterminal Modifications and Unusual Amino Acids

  • The whole peptide has a cyclic structure in which N and C termini are bound to each other.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP00171_predicted_structure.pdb to download.

DRAMP00171

• • Comment

  • No comments found on DRAMP database

• ·Literature 1

• • Title

  • Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12.

• • Pubmed ID

  • 19139222

• • Reference

  • Appl Environ Microbiol. 2009 Mar;75(6):1552-1558.

• • Author

  • Sawa N, Zendo T, Kiyofuji J, Fujita K, Himeno K, Nakayama J, Sonomoto K.

• ·Literature 2

• • Title

  • Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401.

• • Pubmed ID

  • 21948835

• • Reference

  • Appl Environ Microbiol. 2011 Nov;77(22):8164-8170.

• • Author

  • Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K.