General Information

    • DRAMP ID

    • DRAMP00903

    • Peptide Name

    • Hyve A (Plant defensin)

    • Source

    • Australian Hybanthus vernonii

    • Family

    • Belongs to the cyclotide family

    • Gene

    • Not found

    • Sequence

    • RGCYKICGETCLFIPCLTSVFGCSCKN

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Not found

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Cyclotides are plant-derived miniproteins that have the unusual features of a head-to-tail cyclized peptide backbone and a knotted arrangement of disulfide bonds.

    • Helical Wheel Diagram

    • DRAMP00903 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00903.

Physicochemical Information

    • Formula

    • C126H201N33O36S6

    • Absent Amino Acids

    • ADHMQW

    • Common Amino Acids

    • C

    • Mass

    • 2946.54

    • PI

    • 8.33

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +2

    • Boman Index

    • -11.37

    • Hydrophobicity

    • 0.556

    • Aliphatic Index

    • 68.52

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 71.73

    • Polar Residues

    • 15

DRAMP00903

DRAMP00903 chydropathy plot

Comments Information

    • Caution

    • The sequence is incomplete!

Literature Information

  • ·Literature 1

    • Title

    • A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae).

    • Reference

    • Plant Cell. 2005 Nov;17(11):3176-3189.

    • Author

    • Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Göransson U, Craik DJ.