General Information

    • DRAMP ID

    • DRAMP00904

    • Peptide Name

    • Hyca A (Plant defensin)

    • Source

    • Australian Hybanthus calycinus

    • Family

    • Belongs to the cyclotide family

    • Gene

    • Not found

    • Sequence

    • CGETCVVDTRCYTKKCSCAWPVCMRN

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Not found

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Cyclotides are plant-derived miniproteins that have the unusual features of a head-to-tail cyclized peptide backbone and a knotted arrangement of disulfide bonds.

    • Helical Wheel Diagram

    • DRAMP00904 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00904.

Physicochemical Information

    • Formula

    • C120H194N36O37S7

    • Absent Amino Acids

    • FHILQ

    • Common Amino Acids

    • C

    • Mass

    • 2957.5

    • PI

    • 8.33

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -47.13

    • Hydrophobicity

    • -0.119

    • Aliphatic Index

    • 37.31

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7365

    • Absorbance 280nm

    • 294.6

    • Polar Residues

    • 13

DRAMP00904

DRAMP00904 chydropathy plot

Comments Information

    • Caution

    • The sequence is incomplete!

Literature Information

  • ·Literature 1

    • Title

    • A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae).

    • Reference

    • Plant Cell. 2005 Nov;17(11):3176-3189.

    • Author

    • Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Göransson U, Craik DJ.