General Information
-
DRAMP ID
- DRAMP01008
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Peptide Name
- Antifungal lectin PVAP (Plant defensin)
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Source
- Phaseolus vulgaris (Kidney bean)
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Family
- Not found
-
Gene
- Not found
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Sequence
- SNDIYFNFQR
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Sequence Length
- 10
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UniProt Entry
- P84869
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Protein Existence
- Protein level
Activity Information
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Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Mycophaerella arachidicola (IC50=9.8 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01008.
Physicochemical Information
-
Formula
- C59H82N16O18
Absent Amino Acids
- ACEGHKLMPTVW
Common Amino Acids
- FN
Mass
- 1303.4
PI
- 5.55
Basic Residues
- 1
Acidic Residues
- 1
Hydrophobic Residues
- 3
Net Charge
- 0
-
Boman Index
- -35.12
Hydrophobicity
- -1.05
Aliphatic Index
- 39
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 165.56
Polar Residues
- 4
DRAMP01008
Comments Information
Function
- Has hemagglutinating activity towards rabbit erythrocytes. Has antiproliferative activity towards L1210 tumor cell line with an IC50 of 3.6 µM.
Miscellaneous
- Antifungal, antiproliferative and hemagglutinating activity is abolished by incubatio
Literature Information
- ·Literature 1
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Title
- An antifungal protein from flageolet beans
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Pubmed ID
- 16026901
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Reference
- Peptides. 2005 Dec;26(12):2397-2403.
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Author
- Xia L, Ng T.B.