General Information
-
DRAMP ID
- DRAMP01062
-
Peptide Name
- Putative antimicrobial protein 3 (Cm-p2; Plants)
-
Source
- Cenchritis muricatus (Beaded periwinkle)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- SESILIVHQQQSRSSGS
-
Sequence Length
- 17
-
UniProt Entry
- B3EWI8
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01062.
Physicochemical Information
-
Formula
- C75H127N25O29
Absent Amino Acids
- ACDFKMNPTWY
Common Amino Acids
- S
Mass
- 1842.98
PI
- 6.47
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 4
Net Charge
- +1
-
Boman Index
- -43.67
Hydrophobicity
- -0.582
Aliphatic Index
- 85.88
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 7
DRAMP01062
Comments Information
Function
- This peptide demonstrated the capacity to prevent the development of yeasts and filamentous fungi. Otherwise, Cm-p1 displayed no toxic effects against mammalian cells.
Literature Information
- ·Literature 1
-
Title
- Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus.
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Pubmed ID
- 22210491
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Reference
- Biochimie. 2012 Apr;94(4):968-974.
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Author
- L³pez-Abarrategui C, Alba A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva MR, Garay HE, Dias SC, Franco OL, Otero-Gonz¡lez AJ.