General Information

    • DRAMP ID

    • DRAMP01185

    • Peptide Name

    • SPX(1-16)(truncated peptide of Syphaxin; Frogs, amphibians, animals)

    • Source

    • Leptodactylus syphax (Burgundy thin-toed frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVLDILKGAAKDLAGH

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=40.5 µM);
      • Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.1 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01185 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C70H120N20O21

    • Absent Amino Acids

    • CEFMNPQRSTWY

    • Common Amino Acids

    • AGL

    • Mass

    • 1577.84

    • PI

    • 6.75

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • -1.23

    • Hydrophobicity

    • 0.394

    • Aliphatic Index

    • 134.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01185

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax.

    • Reference

    • Toxicon. 2007 Sep 15;50(4):572-580.

    • Author

    • Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F.