General Information

    • DRAMP ID

    • DRAMP01248

    • Peptide Name

    • Dybowskin-1 (Frogs, amphibians, animals)

    • Source

    • Rana dybowskii (Korea brown frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLIGMTHGLICLISRKC

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=12.5 µg/ml), Staphylococcus aureus KCTC3881 (MIC=25 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC 12228 (MIC=60 µg/ml).

    • Hemolytic Activity

      • [Ref:17698251] It has 0.99% hemolytic activity at 100 μg/ml against huamn red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys11 and Cys17)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys11 and Cys17.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01248 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01248.

Physicochemical Information

    • Formula

    • C85H145N23O20S3

    • Absent Amino Acids

    • ADENPQVWY

    • Common Amino Acids

    • IL

    • Mass

    • 1905.41

    • PI

    • 8.96

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • 8.19

    • Hydrophobicity

    • 1.218

    • Aliphatic Index

    • 137.65

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 7.81

    • Polar Residues

    • 6

DRAMP01248

Comments Information

    • Function

    • Dybowskin-1 has low hemolytic activity against human red blood cells (hRBCs).

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.

    • Reference

    • Peptides 2007; 28: 1532-1539.

    • Author

    • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.