General Information

    • DRAMP ID

    • DRAMP01319

    • Peptide Name

    • Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)

    • Source

    • Amolops loloensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA

    • Sequence Length

    • 48

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 µg/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 µg/ml), Bacillus subtilis (MIC=100 µg/ml);
      • Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 µg/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 µg/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 µg/ml).
      • Yeast: Candida albicans ATCC2002 (MIC=50 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01319 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C171H296N86O56

    • Absent Amino Acids

    • CDEFKLMNPQTW

    • Common Amino Acids

    • G

    • Mass

    • 4452.77

    • PI

    • 12.7

    • Basic Residues

    • 13

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +13

    • Boman Index

    • -168.23

    • Hydrophobicity

    • -1.217

    • Aliphatic Index

    • 20.42

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 31.7

    • Polar Residues

    • 30

DRAMP01319

DRAMP01319 chydropathy plot

Comments Information

    • Function

    • Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate.

    • Reference

    • Amino Acids. 2012 Aug;43(2):677-685.

    • Author

    • Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R.