• • DRAMP ID

  • DRAMP01362

• • Peptide Name

  • Frenatin-3 (Frogs, amphibians, animals)

• • Source

  • Litoria infrafrenata (Giant tree frog) (White-lipped tree frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GLMSVLGHAVGNVLGGLFKS

• • Sequence Length

  • 20

• • UniProt Entry

  • P56249

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-negative bacterium: Escherichia coli (MIC=50 µg/ml);
    • Gram-positive bacteria: Leuconostoc mesenteroides (MIC=25 µg/ml), Bacillus cereus (MIC=12.5 µg/ml), Micrococcus luteus (MIC=1.5 µg/ml), Pastewella haemolytica (MIC=0.8 µg/ml), Streptococcus uberis (MIC=50 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01362_predicted_structure.pdb to download.

DRAMP01362

• • Function

  • Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell.

• • Tissue specificity

  • Expressed by the skin parotoid and/or rostral glands.

• ·Literature 1

• • Title

  • The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata.

• • Pubmed ID

  • 9225251

• • Reference

  • J Pept Sci. 1996 Mar-Apr;2(2):117-124.

• • Author

  • Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.