General Information
-
DRAMP ID
- DRAMP01402
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Peptide Name
- Odorranain-J-OA1 (Frogs, amphibians, animals)
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Source
- Odorrana grahami (Yunnanfu frog)
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Family
- Not found
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Gene
- Not found
-
Sequence
- GLFTLIKGAYKLDAPTVACN
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 µg/ml);
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 µg/ml);
- Yeast: Candida albicans ATCC 2002 (MIC=20.1 µg/ml).
-
Hemolytic Activity
-
- [Ref:22029824]Not found
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01402_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C96H155N23O27S
Absent Amino Acids
- EHMQRSW
Common Amino Acids
- AL
Mass
- 2095.48
PI
- 8.18
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- 3.55
Hydrophobicity
- 0.545
Aliphatic Index
- 107.5
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 78.42
Polar Residues
- 7
DRAMP01402
Comments Information
Function
- Weakly active against bacteria and fungi.
Literature Information
- ·Literature 1
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Title
- Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
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Pubmed ID
- 22029824
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Reference
- J Proteome Res. 2012 Jan 1;11(1):306-319.
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Author
- Yang X, Lee WH, Zhang Y.